| The Science of WinterWell
Andrographis (Andrographis paniculata) leaf is traditionally used in Ayurveda and Traditional Chinese medicine to support healthy upper respiratory tract function.1,2 Double-blind, placebo controlled clinical trials support the traditional use of Andrographis.3,4 In clinical trials with over 1300 subjects, Andrographis proved effective taken alone or combined with other herbal ingredients.5,6 Holy Basil (Ocimum sanctum) is related to common basil and in the Ayurvedic tradition the leaves are used to support healthy upper respiratory tract function.7-9 Research has shown that Holy Basil holds numerous potential health benefits, including support of healthy immune system function.10 Ashwagandha (Withania somnifera) is renowned as an herbal adaptogen. In the Indian Ayurvedic tradition the root is used as a Rasayana, a dietary supplement or practice promoting rejuvenation, mental and physical health, as well as providing a defense against aging and challenging environmental factors.11 Research has shown that Ashwagandha root extracts support healthy immune system function.12-14 Trikatu or the 'three pungent spices', is a traditional formula used to support healthy upper respiratory tract function.15 It consists of equal parts of Long Pepper fruit (Piper longum), Black Pepper fruit (Piper nigrum), and Ginger root (Zingiber officinale). It can also enhance the bioavailability of other herbal products taken at the same time.16,17 References below. Directions
1 capsule, two to three times per day or as directed by your health care practitioner. Not for use during pregnancy. If you are nursing a baby or taking any prescription drugs, seek the advice of a health professional before using this product. Not to be taken by children under 12. Keep out of reach of children. Care for the Environment
As a manufacturer, our actions can have a large impact on the environment. We always look for the most earth-friendly, sustainable choice. All Ayurceutics products feature: -
Vegetarian capsules and tablets with no animal-derived ingredients -
Extraction using only pure water & alcohol, not toxic solvents -
Non-irradiated herbs -
Organic cotton stuffing -
Bottles that are easily recyclable #2 plastic, HDPE 
| *This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. | Click here to read the actual references below and search for more detailed information on the herbs in WinterWell. The PupMed database is operated by the National Library of Medicine and is an excellent resource for researching scientific literature on herbs. References
1. Nadkarni AK. Indian Materia Medica. Vol. 1. Bombay, India: Popular Prakashan; 1976:101-3. 2. Tu G et al. (eds.). Pharmacopoeia of the People's Republic of China. Guangzhou, China: Guangdong Science and Technology Press; 1992:90. 3. Caceres DD et al. Use of visual analogue scale measurements (VAS) to assess the effectiveness of standardized Andrographis paniculata extract SHA-10 in reducing the symptoms of common cold. A randomized double blind-placebo study. Phytomedicine. 1999;6:217-23. 4. Melchior J et al. Controlled clinical study of standardized Andrographis paniculata extract in common cold - a pilot study. Phytomedicine. 1996/97;3:315-8. 5. Coon JT, Ernst E. Andrographis paniculta in the treatment of upper respiratory tract infections: A systematic review of safety and efficacy. Planta Med. 2004;70:293-8. 6. Poolsup N et al. Andrographis paniculata in the symptomatic treatment of uncomplicated upper respiratory tract infection: Systematic review of randomized controlled trials. J Clin Pharm Ther. 2004;29:37-45. 7. Jain SK and DeFilipps RA. Medicinal Plants of India. Vol. 1. Algonac, MI: Reference Publications; 1991:3723. 8. Kirtikar KR, Basu BD, An ICS. Indian Medicinal Plants. Vol. 3. Dehra Dun, India: Bishen Singh Mahendra Pal Singh; 1994:1965-8. 9. Nadkarni AK. Indian Materia Medica. Vol. 1. Bombay, India: Popular Prakashan; 1976:865-7. 10. Godhwani A, et al. Ocimum sanctum - a preliminary study evaluating its immunoregulatory profile in albino rats. J Ethnopharmacol. 1988;24:193-8. 11. Bhattacharya A et al. Antioxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol. 2001;74:1-6. 12. Dhuley JN. Effect of some Indian herbs on macrophage functions in ochratoxin A treated mice. J Ethnopharmacol. 1997;58:15-20. 13. Dhuley JN. Therapeutic efficacy of ashwagandha against experimental aspergillosis in mice. Immunopharmacol Immunotoxicol. 1998;20:191-8 14. Ziauddin M et al. Studies on the immunomodulatory effects of ashwagandha. J Ethnopharmacol. 1996;50:69-76. 15. Dash VB, Junius AMM. A Handbook of Ayurveda. New Delhi, India: Concept Publishing; 1983:195-196. 16. Shoda G et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64:353-6. 17. Lambert JD et al. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. J Nutr. 2004;134:1948-52. | 
